Saturday night live has gone through its ups and downs over the years. I will not chronicle the successes and failures of SNL in this post.
However, I would like to point out that SNL has continually strengthened over the past year. The writers and actors are hitting their stride just at the right time...they have PLENTY of material with the 2008 Presidential Race.
After a 4 month hiatus because of the writer's strike, SNL has had 2 new shows. Last night's was one of the funniest episodes I have seen in some time, and included notable cameos from Hillary Clinton and Rudy Giuliani.
The first skit was a mock democratic debate by NBC News in Cleveland. "Brian Williams" and "Tim Russert" couldn't help but show their bias and praise for Obama, and their disdain for Sen. Clinton. Hillary then followed with a live rebuttal, in which she confronted Amy Poehler. Darrell Hammond was excellent at impersonating Russert and his style, and, overall, it was quite amusing...check it out:
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7 comments:
Hillary's cameo was good...time to pull out all the stops. But notice when Amy asked how the campaign was going, Hillary said, "Fine. Why, did you hear something different?" That showed a good sense of perspective.
Darrell Hammond is a genius. I'm glad you mentioned the TV funhouse cartoon b/c that was Hammond as Jesse...and it was 8 years ago or whenever that Hammond first did Jesse on SNL. The audience didn't quite know what to do w/ a white man impersonating a black man but it was so perfectly nuanced that you had to be impressed.
on a totally unrelated note -- Steve -- what is the evolutionary purpose of cold diuresis? It seems counterintuitive.
I agree, SNL has been better than I've seen it is a while. And this past week was better than last week. Loved Hillary but afraid it might be too little too late.
Could the evolutionary role for cold diuresis be that it "costs" more to keep higher volume warm, thus the body's response to expel any excess? I know I'm not Steve so probably totally off base.
that makes sense... let's see if Steve can come up with anything better
Kath/Steve what was bottom line of norepi vs. vasopressin (NEJM this week) for sepsis? i couldn't get it online
Wow, I never thought a post on SNL would induce a talk about "cold diuresis".
Anyway, the proported mechanism of cold diuresis is the following:
1. Cold stimulates hormonal stress response, including increase in ACTH and norepinephrine
2. The catechols result in vasoconstriction and an increase systemic blood pressure
3. The rise in blood pressure decreases the the afferent baroreceptor response which then decreses ADH release
4. The fall in ADH results in an increase in free water diuresis
5. This occurs despite renal vasoconstriction and a drop in overall GFR
So, bottom line, cold ends up lowering AVP (ADH) which results in an inability to reabsorb H20 in the collecting ducts.
Melissa will be pleased with this response.
Plus, Steve, thank you for the synopsis of all the political sketches on SNL. I am normally not awake for SNL but the political sketches are my favorites so it's nice to see them all in one place.
No mortality difference btw vaso and norepi in patients with septic shock, suggestion of some benefit in patients rec'ing vaso with less severe shock.
Will, did you know Nat Geo TV station had an hour long program on heroin? Pretty interesting, and depressing...
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